The Role of CoREST in Gene Silencing
Wagner, Roland Nikolaus
In eukaryotic organisms a variety of DNA-protein, as well as protein-protein interactions organize in an elaborated way to elicit proper regulation of differential gene expression critical for developmental processes including neurogenesis. Gene silencing induced by the generation of an inactive chromatin state is becoming increasingly appreciated as an important mechanism of transcriptional regulation. CoREST was initially identified as REST-...